Electrocatalytic cascade multicomponent assembling: stereoselective one-pot synthesis of the substituted 3-azabicyclo[3.1.0]hexane-1-carboxylate system from aldehyde, malononitrile, malonate and methanol

Electrolysis of aromatic aldehydes, malononitrile and malonate in methanol in an undivided cell in the presence of sodium bromide-sodium methoxide as double mediatory system results in the stereoselective formation of methyl (1R∗,5R∗,6R∗) 6-substituted 5-cyano-4,4-dialkoxy-2-oxo-3-azabicyclo[3.1.0]hexane-1-carboxylates in 50-70% yields.