On-resin cyclization of a head-to-tail cyclopeptide using an allyldimethylsilyl polystyrene resin pre-loaded by metathesis

A functionalized anti-angiogenic cyclo-peptide was synthesized under partially protected or deprotected form on an allyldimethylsilyl polystyrene support loaded by metathesis with a conveniently functionalized d-Tyrosine amino-acid.