Three-component synthesis of polysubstituted benzene derivatives via Diels–Alder reaction of cyclopentadienone acetal with alkyne

An efficient and regioselective synthesis of polysubstituted benzene derivatives was achieved via multicomponent reaction of a substituted cyclopropenone acetal and two alkyne molecules. The synthesis utilizes cyclopentadienone acetal as an intermediate and enables regioselective [2+2+2] assembly of the three-components into a benzene ring. A variety of polysubstituted benzene derivatives of synthetic and structural interest have been synthesized.

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