کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5229416 1383662 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of (−)-diospongins A and B and their stereoisomers at C-5
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Stereoselective synthesis of (−)-diospongins A and B and their stereoisomers at C-5
چکیده انگلیسی

Antiosteoporotic diarylheptanoids (−)-diospongins A (1) and B (2) were synthesized stereoselectively. The key steps in the synthesis include a stereospecific PdII-catalyzed cyclization of chiral 1,5,7-trihydroxy-2-heptenes, 6a and 6b, to form cis and trans tetrahydropyran rings and a regioselective Wacker oxidation of β-(tetrahydro-2H-pyran-2-yl)styrenes, 5a and 5b. Their C-5 epimers 3 and 4 were also synthesized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 63, Issue 37, 10 September 2007, Pages 9049-9056
نویسندگان
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