کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5230208 | 1383688 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrophilic monofluoromethylation of O-, S-, and N-nucleophiles with chlorofluoromethane
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Electrophilic monofluoromethylation of O-, S-, and N-nucleophiles with chlorofluoromethane Electrophilic monofluoromethylation of O-, S-, and N-nucleophiles with chlorofluoromethane](/preview/png/5230208.png)
چکیده انگلیسی
CH2ClF has been found to be a useful electrophilic monofluoromethylating agent for a variety of O-, S-, and N-nucleophiles. The reaction is not sensitive to the radical scavenger such as nitrobenzene, which strongly supports an SN2 mechanism rather than an SET mechanism. Although most of these products (fluoromethyl ethers, sulfides, and amines) can be isolated with good purity, some of these compounds do intend to decompose (via defluorination) during storage. The electrophilic monofluoromethylation of carbon-nucleophiles was attempted with CH2ClF, CH2FI, or FCH2OTs as monofluoromethylating agents, but with no success.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 63, Issue 43, 22 October 2007, Pages 10569-10575
Journal: Tetrahedron - Volume 63, Issue 43, 22 October 2007, Pages 10569-10575
نویسندگان
Wei Zhang, Lingui Zhu, Jinbo Hu,