The design, synthesis, and characterization of a PAMAM-based triple helical collagen mimetic dendrimer

The synthesis and characterization of a collagen mimetic dendrimer composed of Gly-Pro-Nleu sequence is described. The dendrimer is built on a lsquofirst generationrsquo poly(amidoamine) core and is synthesized in 38% yield. This dendrimer exhibits a melting temperature of 25 degC, which is in between previously studied analogous molecules of identicalsequence and length.