Correlation between pressure and steric interactions in organic reactions

ΔVi*=ΔV0*+ΔVσ* (ΔV0*: activation volume of the unhindered reaction, ΔVσ*: steric volume component) The paper reviews the recent progress made in the high-pressure relief of steric inhibition in congested reactions. The correlation between pressure and steric interactions is illustrated by comprehensive examples and rationalized via useful Hammond postulate. The report contains 96 references.