کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5232319 1383758 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorinated alcohol directed formation of dispiro-1,2,4,5-tetraoxanes by hydrogen peroxide under acid conditions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Fluorinated alcohol directed formation of dispiro-1,2,4,5-tetraoxanes by hydrogen peroxide under acid conditions
چکیده انگلیسی

The oxidative system MTO/30%H2O2/HBF4/fluorous alcohol is promising for the selective synthesis of biologically important antimalarial dispiro-1,2,4,5-tetraoxanes by direct acid-catalysed cyclisation of various 4-substituted cyclohexanones (1, R=Me, Et, tBu, Ph, COOEt, CF3). The role of the substitutent at the 4-position was important in the selectivity of formation of tetraoxane (2, TO) with respect to hexaoxonane (3, HO). By the use of fluorinated alcohols and under the right reaction conditions, tetraoxanes 2 were selectively formed and synthesised in 46-86% isolated yield from 4-substituted cyclohexanones 1.

Graphical Abstract

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 62, Issue 7, 13 February 2006, Pages 1479-1484
نویسندگان
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