Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.