کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5261479 | 1385146 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brominated resorcylic acid lactones from the marine-derived fungus Cochliobolus lunatus induced by histone deacetylase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: Brominated resorcylic acid lactones from the marine-derived fungus Cochliobolus lunatus induced by histone deacetylase inhibitors Brominated resorcylic acid lactones from the marine-derived fungus Cochliobolus lunatus induced by histone deacetylase inhibitors](/preview/png/5261479.png)
چکیده انگلیسی
Chemical epigenetic manipulation was applied to the marine-derived fungus Cochliobolus lunatus (TA26-46) with histone deacetylase inhibitors, resulting in significant changes of the secondary metabolites. Two new 14-membered resorcylic acid lactones characterized with bromine substitution, 5-bromozeaenol (1) and 3,5-dibromozeaenol (2), together with four known analogues (3-6), were isolated from the culture treated with sodium butyrate. The absolute configurations of 1 and 2 were assigned by CD spectra and chemical conversion. Compounds 1 and 2 represent the first example of natural brominated resorcylic acid lactones. These brominated lactones were exclusively obtained from C. lunatus (TA26-46) following epigenetic modifying treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 35, 27 August 2014, Pages 4888-4891
Journal: Tetrahedron Letters - Volume 55, Issue 35, 27 August 2014, Pages 4888-4891
نویسندگان
Wei Zhang, Chang-Lun Shao, Min Chen, Qing-Ai Liu, Chang-Yun Wang,