کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5261609 | 1385151 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Total synthesis of epicoccamides A and D via olefin cross-metathesis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Epicoccamides A and D were synthesized through a route that utilizes fragment coupling via olefin cross-metathesis as a key step. The right-hand segment of the epicoccamides was synthesized by a tandem O-acylation-migration reaction, and the left-hand segments were stereoselectively synthesized through a modified version of Crich's β-selective mannosylation. The previously assigned absolute configuration of the epicoccamide D was confirmed, and that of epicoccamide A was assigned as (5S,2â²S) based on the NMR and CD spectra. This Letter provides the first example of the total synthesis of epicoccamide A.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 31, 30 July 2014, Pages 4350-4354
Journal: Tetrahedron Letters - Volume 55, Issue 31, 30 July 2014, Pages 4350-4354
نویسندگان
Arata Yajima, Akihiro Kawajiri, Ayaka Mori, Ryo Katsuta, Tomoo Nukada,