کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5262266 1385172 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Palladium-catalyzed allylic alkylation using chiral P,O-ligands synthesized via sulfonamide directed ortho-lithiation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Palladium-catalyzed allylic alkylation using chiral P,O-ligands synthesized via sulfonamide directed ortho-lithiation
چکیده انگلیسی
An efficient approach for the synthesis of chiral P,O-ligands containing sulfonamide and phosphine moieties is designed. The introduction of the chirality is achieved through different stereogenic groups attached to the sulfonamide nitrogen. The highly effective sulfonamide directed ortho-lithiation and the subsequent reaction with ClPPh2 is the key step in the synthesis of the ligands. The prepared P,O-compounds are applied in Pd-catalyzed asymmetric allylic alkylation (AAA) under optimized conditions, to obtain high degrees of enantioselectivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 13, 26 March 2014, Pages 2093-2096
نویسندگان
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