A novel and one-pot method for synthesis of unprecedented 3,3-dimethyl-2-amide indoles under metal-free conditions

A novel and efficient method for the synthesis of 3,3-dimethyl-2-amide indoles, employing a I2/DMSO-promoted oxidative amidation reaction between 1,2,3,3-tetramethyl-3H-indolium iodide and cyclic secondary amines under metal-free conditions has been developed.