کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5263435 | 1385214 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of the tetrahydrofuran unit of varitriol and γ-butyrolactones from 5-oxabicyclo[2.1.1]hexane derivative via oxidative cleavage reactions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of the tetrahydrofuran unit of varitriol and γ-butyrolactones from 5-oxabicyclo[2.1.1]hexane derivative via oxidative cleavage reactions Synthesis of the tetrahydrofuran unit of varitriol and γ-butyrolactones from 5-oxabicyclo[2.1.1]hexane derivative via oxidative cleavage reactions](/preview/png/5263435.png)
چکیده انگلیسی
A formal synthesis of marine-derived antitumor natural product varitriol from a 5-oxabicyclo[2.1.1]hexane derivative is described. A tetrahydrofuran unit of varitriol embedded with four contiguous stereocenters was synthesized with an overall yield of 10.2% in 11 steps from an oxa-bicyclic system. An unprecedented oxidative cleavage reaction involving scissoring of two CC bonds at oxa-quaternary carbon of THFs leading to γ-butyrolactones was reported and a plausible mechanism has been proposed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 14, 2 April 2014, Pages 2266-2269
Journal: Tetrahedron Letters - Volume 55, Issue 14, 2 April 2014, Pages 2266-2269
نویسندگان
Surendra H. Mahadevegowda, Faiz Ahmed Khan,