کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5264182 | 1385245 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facile synthesis of novel tetrasubstituted 1-pyrazolines from Baylis-Hillman adducts and acyl diazomethanes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An efficient method for the regioselective synthesis of potentially biologically active tetrasubstituted 1-pyrazolines has been achieved via a 1,3-dipolar cycloaddition reaction. A range of tetrasubstituted 1-pyrazolines bearing one Boc group and two ester groups were obtained in high yields (up to 99%). The structure and relative stereochemistry of cycloadducts were confirmed by NMR spectra and single crystal X-ray diffraction. The possible mechanism was proposed and the major Z-cycloadducts as a single diastereomer could be separated from each other by chromatography.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 29, 17 July 2013, Pages 3846-3850
Journal: Tetrahedron Letters - Volume 54, Issue 29, 17 July 2013, Pages 3846-3850
نویسندگان
Hongbao Sun, Xiaoyan Wang, Miao Zhan, Jie Liu, Yongmei Xie,