Stereoselective total synthesis of crucigasterins A, B and D through a common intermediate

The first stereoselective total synthesis of the marine-derived antimicrobial amino-alcohols, crucigasterins A, B and D has been accomplished through a common intermediate starting from pent-3-en-1-ol. The method involves the Sharpless asymmetric aminohydroxylation and Julia and Wittig olefinations as the key steps.