کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5264405 | 1385254 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induced production of depsipeptides by co-culturing Fusarium tricinctum and Fusarium begoniae
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Induced production of depsipeptides by co-culturing Fusarium tricinctum and Fusarium begoniae Induced production of depsipeptides by co-culturing Fusarium tricinctum and Fusarium begoniae](/preview/png/5264405.png)
چکیده انگلیسی
A co-culture of Fusarium tricinctum and Fusarium begoniae induced the production of two new linear depsipeptides, subenniatins A and B (1-2), which were not detected when either of the two fungi was cultured alone. The structures of the new compounds were unambiguously determined by analysis of 1D, 2D NMR, and mass spectra, as well as by chemical transformation. Complex NMR spectra were observed for compounds 1 and 2, which were attributed to the presence of rotamers as revealed by 1D NOE and ROESY measurements. Structurally, compounds 1 and 2 are biogenetic building blocks of the cytotoxic enniatins B, B1, A1, and A, which are the major metabolites of F. tricinctum when this fungus is cultured alone. Compounds 1 and 2 were found to be inactive in cytotoxic and antibacterial assays.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 20, 15 May 2013, Pages 2492-2496
Journal: Tetrahedron Letters - Volume 54, Issue 20, 15 May 2013, Pages 2492-2496
نویسندگان
Jian-ping Wang, Wenhan Lin, Victor Wray, Daowan Lai, Peter Proksch,