Stereoselective construction of cis-decalin framework via radical domino cyclization

Steroids with A/B cis-decalin moiety and various bioactivities have attracted many synthetic chemists as target molecules and development of efficient methodology providing cis-decalins has been desired. A stereoselective domino cyclization via Mn(OAc)3 and Cu(OTf)2-mediated radical reaction was found to be effective to construct cis-decalin framework.