Solventless convenient synthesis of new cyano-2-aminopyridine derivatives from enaminonitriles

A synthesis of novel 4-substituted-3-cyano-2-aminopyridines using enaminonitriles and various primary amines was established under microwave irradiation and solvent-free conditions. Structures of the new compounds were characterized by IR, MS, 1H and 13C NMR data and the structure of 2-aminopyridine of the products was confirmed by X-ray analysis.