کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5264843 | 1385269 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Candida antarctica lipase A and Pseudomonas stutzeri lipase as a pair of stereocomplementary enzymes for the resolution of 1,2-diarylethanols and 1,2-diarylethanamines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Candida antarctica lipase A (CALA) and Pseudomonas stutzeri lipase (PSL) displayed opposite enantioselectivities in the acylation of 1,2-diphenylethanol and 1,2-diphenylethanamine. CALA was (S)-selective while PSL was (R)-selective. In addition, fourteen different 1,2-diarylethanols were tested as the substrates of CALA. It was found that most of them were accepted by CALA with high enantioselectivity. The DKR of five representative substrates by the combination of CALA and a ruthenium-based racemization catalyst provided good yields (82-91%) and acceptable enantiopurities (87-94% ee).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 10, 6 March 2013, Pages 1185-1188
Journal: Tetrahedron Letters - Volume 54, Issue 10, 6 March 2013, Pages 1185-1188
نویسندگان
Sol Kim, Yoon Kyung Choi, Jieun Hong, Jaiwook Park, Mahn-Joo Kim,