کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5264928 1385270 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Convenient strategy for the synthesis of highly functionalizable hydroxylated unsaturated azepanes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Convenient strategy for the synthesis of highly functionalizable hydroxylated unsaturated azepanes
چکیده انگلیسی
A convenient approach to the construction of dihydroxylated unsaturated azepanes featuring a functional group (ethoxycarbonyl)methyl or (cyano)methyl at C-2 was achieved from a pent-4-enal synthon obtained in four steps from d-xylose. The key step of the sequence relied on the conjugate addition of allylamine to α,β-unsaturated ester or nitrile, prepared by Wadsworth-Emmons olefination. Subsequent RCM afforded the target unsaturated azepanes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 33, 15 August 2012, Pages 4440-4443
نویسندگان
, , , , ,