A novel approach for highly regio- and stereoselective synthesis of (Z)-3-methyleneisoindoline-1-ones in aqueous micellar medium

An environmentally benign and operationally simple methodology was developed for the regio- and stereoselective synthesis of (Z)-3-methyleneisoindolinones in aqueous micellar medium from 2-iodo-N-phenyl-benzamides and terminal alkyne by Cu-free domino Sonogashira reaction followed by 5-exo-dig-cyclization using Pd(CH3CN)Cl2 as catalyst and 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene as ligand under aerobic condition.