An efficient synthesis for eslicarbazepine acetate, oxcarbazepine, and carbamazepine

Efficient methods have been developed for the synthesis of three active pharmaceutical ingredients (APIs) carbamazepine (Tegretol®) 1, oxcarbazepine (Trileptal®) 2, and eslicarbazepine acetate (Exalief®) 3 by employing enantioselective reduction and carboxamidation reaction.