کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5265721 | 1385292 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
First chemical synthesis report of an anthocyanin metabolite with in vivo occurrence: cyanidin-4â²-O-methyl-3-glucoside
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: First chemical synthesis report of an anthocyanin metabolite with in vivo occurrence: cyanidin-4â²-O-methyl-3-glucoside First chemical synthesis report of an anthocyanin metabolite with in vivo occurrence: cyanidin-4â²-O-methyl-3-glucoside](/preview/png/5265721.png)
چکیده انگلیسی
Anthocyanins are natural polyphenolic compounds with important biological properties. In humans , these compounds are metabolized into different derivatives namely methyl, glucuronyl, and sulfate conjugates. Among these, cyanidin-4â²-O-methyl-3-glucoside, already detected in vivo, seems to be an interesting metabolite to be used as standard for biological studies. The lack of suitable standards is a major drawback in biological studies. Bearing this in mind, this work describes a strategy for the chemical synthesis of cyanidin-4â²-O-methyl-3-glucoside 9, which involved in the synthesis of the 'Western' and 'Eastern' molecules, namely 2,4-diacetoxy-6-hydroxybenzaldehyde 2 and 2-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyloxy)-3â²-benzyloxy-4â²-methoxyacetophenone 8, respectively. The final step consisted in the Robinson's acidic aldol condensation between 2 and 8 molecules, which after the respective deprotections yield product 9.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 22, 29 May 2013, Pages 2865-2869
Journal: Tetrahedron Letters - Volume 54, Issue 22, 29 May 2013, Pages 2865-2869
نویسندگان
LuÃs Cruz, Nuno Mateus, Victor de Freitas,