کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5265984 1385299 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
6-Hydroxymethyltriazolyl-6-deoxy-β-cyclodextrin: a highly water soluble and structurally well-defined β-cyclodextrin click cluster
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
6-Hydroxymethyltriazolyl-6-deoxy-β-cyclodextrin: a highly water soluble and structurally well-defined β-cyclodextrin click cluster
چکیده انگلیسی
The structural, physical, and biological properties of heptakis{6-(4-hydroxymethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}-β-cyclodextrin (HTβCD) were investigated by a variety of methods, including NMR, UV/vis, circular dichroism spectroscopy, computer modeling, turbidity testing, Ka measurements, and the MTT assay. The experimental results suggest that HTβCD is structurally well-defined, highly water-soluble, and has low cytotoxicity. These advantages of HTβCD versus β-CD indicate that β-cyclodextrin click clusters may function both as host molecules and as potential, alternative excipients to β-CD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 43, 24 October 2012, Pages 5791-5795
نویسندگان
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