کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5266171 1385304 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reactivity of cyclic sulfamidates towards lithium acetylides: synthesis of alkynylated amines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Reactivity of cyclic sulfamidates towards lithium acetylides: synthesis of alkynylated amines
چکیده انگلیسی
A synthetically useful level of reactivity of cyclic sulfamidates toward acetylides is described. Ring-opening reactions of a structurally diverse set of 1,2- and 1,3-cyclic sulfamidates with a range of lithium acetylides from aliphatic, cyclic, aromatic, heteroaromatic, and functionalized alkynes proceed smoothly in a regioselective manner to give the corresponding N-sulfate intermediates. Hydrolysis of these intermediates under acidic conditions furnishes the alkynylated amines in yields ranging from 29% to 98%. The scope of the acetylenic substitution reaction with the structural variations in both the cyclic sulfamidates and alkynes is briefly examined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 48, 30 November 2011, Pages 6336-6341
نویسندگان
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