کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5266245 1385305 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one
چکیده انگلیسی
Performing Jefford's cyclization of ethyl 2-pyrrol-1-ylcyclohex-2-ene-1-carboxylate (5) using boron tribromide in refluxing dichloromethane led to a trans-cis bromopyrrolohydrindolone 7 whose debromination in alkaline medium afforded a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one 6. Compound 7 and two of its diastereoisomers were synthesized in order to better understand this unusual reaction and more generally the reactivity of these systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 9, 27 February 2013, Pages 1133-1136
نویسندگان
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