Conducting moisture sensitive reactions under mechanochemical conditions

Dry organic solvents are used for various organic reactions that employ moisture sensitive reagents. The processes to dry these solvents are hazardous and costly. Setting up reactions in an open atmosphere while using moisture sensitive reagents has little to no effect on the rate or yield of the reaction under solvent-free mechanochemical conditions. We believe this is partly due to the gaseous nature of the water vapor in the air compared to the dissolved water and oxygen in solution.