Convergent enantioselective syntheses of two potential C25-C40 subunits of (−)-caylobolide A

The convergent syntheses of two possible diastereomers of the C25-C40 subunit resident in (−)-caylobolide A have been accomplished. The key reaction featured a chemoselective Ru-catalyzed cross-metathesis between a fully elaborated type I and two functionalized type II α,β-unsaturated ketones.