Sequential alkylation/gold-catalyzed annulation reactions of anilines with propargylic bromide derivatives

Preliminary results of sequential alkylation/gold-catalyzed annulation reactions of anilines with propargylic bromide derivatives to provide quinoline scaffolds are described. The efficiency of NaAuCl4·2H2O in the sequential procedure was investigated and compared with different transition metal salts and Au(I) complexes. Selectivity of the reaction of aniline derivatives with propargylic bromides has also been investigated.