کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5266988 | 1385326 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The synthesis of C-13 functionalized pleuromutilins via C-H amidation and subsequent novel rearrangement product
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The synthesis of C-13 functionalized pleuromutilins via C-H amidation and subsequent novel rearrangement product The synthesis of C-13 functionalized pleuromutilins via C-H amidation and subsequent novel rearrangement product](/preview/png/5266988.png)
چکیده انگلیسی
Multi-gram quantities of C-13 functionalized pleuromutilin intermediates were synthesized under mild conditions via C-H amidation chemistry. The initial work was performed using rhodium catalysis. However, the highest yields were achieved using silver catalysis, resulting in stereoselective oxazolidinone formation. The ring closure was performed in the presence of a C-12 vinyl group, which differentiates it from historical methods involving the saturated pleuromutilin skeleton. A highlight of this vinyl template is a unique tetracyclic rearrangement product that can be generated from its treatment with hydrochloric acid and heat.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 33, 17 August 2011, Pages 4247-4251
Journal: Tetrahedron Letters - Volume 52, Issue 33, 17 August 2011, Pages 4247-4251
نویسندگان
Daniel P. Uccello, Shawn M. Miller, Noah A. Dieterich, Antonia F. Stepan, SeungWon Chung, Kathleen A. Farley, Brian Samas, Jinshan Chen, Justin I. Montgomery,