InCl3-catalyzed synthesis of C-pyrrolyl glycosides via tandem condensation of aminosugars and 1,3-dicarbonyl compounds in water

Various C-pyrrolyl glycosides were obtained through tandem condensation of aminosugars (d-glucosamine and d-galactosamine) and 1,3-dicarbonyl compounds under green conditions in moderate to good yields. The reactions were carried out in the presence of 10 mol % InCl3 in water at 50 °C. A reaction mechanism through carbocation intermediates was proposed.