Highly diastereoselective addition of allyltitanocenes to α-chiral ketones

The addition of allyltitanium reagents, generated by the desulfurizative titanation of allylic sulfides with the titanocene(II) reagent Cp2Ti−1-butene, to α-chiral ketones produced tertiary homoallylic alcohols bearing three adjacent chiral centers with high diastereoselectivity.

Figure optionsDownload as PowerPoint slide