Cu(OAc)2·H2O-an efficient catalyst for Huisgen-click reaction in supercritical carbon dioxide

An efficient protocol for Huisgen-click reaction catalyzed by Cu(OAc)2·H2O for the synthesis of 1,4-disubstituted triazoles has been developed in supercritical carbon dioxide (scCO2) in the absence of ligand at 36 °C. The protocol could afford the corresponding products in excellent yield at very low catalyst loadings (0.01 mol %).