کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5268024 1385352 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydroxymethylation of α-substituted nitroacetates
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hydroxymethylation of α-substituted nitroacetates
چکیده انگلیسی
Only 1 mol % of K3PO4 is efficient enough to catalyze the hydroxymethylation of α-substituted nitroacetates in good to excellent yield. Both aliphatic and aryl substituted nitroacetates work well under this reaction. The first catalytic asymmetric version of this reaction also reported that 10 mol % of cupreidine could catalyze this reaction up to 71% ee and 89% yield. Paraformaldehyde and formalin could both serve as the hydroxymethylation C1 unit. The synthetic application of products is also demonstrated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 46, 16 November 2011, Pages 6118-6121
نویسندگان
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