A general, concise, ‘collective’ approach to eudesmanolide sesquiterpenoids: total synthesis of bioactive atractylenolides I–IV and related natural products

Total synthesis of seven bioactive atractylenolide-type eudesmanolides from Hagemann’s ester, following, a short, scalable, adaptable, and diversity oriented protocol, has been accomplished. This effort opens a gateway to access through synthesis an exceptionally potent and promising group of natural products and their congeners of contemporary interest.

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