An atom-economic green approach: oxidative synthesis of functionalized 1,4-dihydropyridines from N,N-dimethylenaminones and amines

We report the first oxidative condensation between N,N-dimethylenaminones with amines to form 1,4-dihydropyridines in moderate to good yields, promoted by oxone and trifluoroacetic acid in PEG-400. This reaction features an unusual oxidation of in situ formed dimethylamine to efficiently provide the 4-methylene of 1,4-dihydropyridines, and a highly environment-friendly reaction condition.

Figure optionsDownload as PowerPoint slide