کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5268495 1385364 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-phase synthesis of fused 1,4-diazepanone peptidomimetics via tandem N-iminium ion cyclization-nucleophilic addition
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Solid-phase synthesis of fused 1,4-diazepanone peptidomimetics via tandem N-iminium ion cyclization-nucleophilic addition
چکیده انگلیسی

We herein describe the solid-phase synthesis of protected N-oxoalkyl-derivatized peptides designed for subsequent acid-mediated, tandem N-acyliminium ion cyclization-nucleophilic addition reaction. The target compounds contained fused 1,4-diazepanones incorporated into a peptide backbone and served as conformational constraints. The scope and limitation of the ring formation were studied, and the structural requirements and reaction conditions for cyclization are outlined.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 56, Issue 40, 30 September 2015, Pages 5424-5428
نویسندگان
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