Copper(II) fluoride-catalyzed N-arylation of heterocycles with halothiophenes

A novel, cheap copper(II) fluoride-mediated N-arylation of heterocycles with halothiophenes is described. The yield of the pyrazolylthiophene strongly depends on the nature of the initial thiophene. The molecular structure of 3,5-dimethyl-1-(5′-methyl-[2,2′]bithienyl-5-yl)-1H-pyrazole was studied by X-ray diffraction.

Copper(II) fluoride-mediated N-arylation of heterocycles with halothiophenes is described. The yield of the pyrazolylthiophene depends strongly on the nature of the initial thiophene.Figure optionsDownload as PowerPoint slide