VB1-Al2O3-catalyzed one-pot condensation of aromatic ketone, aromatic aldehyde, and amide

A novel and green approach for the efficient synthesis of β-amido ketones using VB1-Al2O3 as a heterogeneous catalyst for the first time from an aldehyde, enolizable ketones, and an amide in EtOH is described. The present methodology has several advantages from the economical and environmental points of view, such as simple procedure, low catalyst loading, high atom economy, and good yields.