کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5268987 | 1385378 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A selective and direct synthesis of 2-bromo-4-alkylthiophenes: Convenient and straightforward approaches for the synthesis of head-to-tail (HT) and tail-to-tail (TT) dihexyl-2,2â²-bithiophenes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A clean and selective method for the synthesis of 2-bromo-4-alkylthiophenes (5a-c) was developed, and the desired products were obtained in excellent yields (>90%). The proposed methodology was based on the regioselective lithiation of 3-alkylthiophenes (1a-c) with n-BuLi at â78 °C and the reaction of the lithiated intermediate with bromine. A simple and efficient protocol for the synthesis of dihexyl-2,2â²-bithiophenes from 2-bromo-4-hexylthiophene (5b) was developed via Kumada and Suzuki cross-coupling reactions in high yields (>90%) and excellent selectivity for the head-to-tail (HT) and tail-to-tail (TT) regioisomers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 51, Issue 34, 25 August 2010, Pages 4526-4529
Journal: Tetrahedron Letters - Volume 51, Issue 34, 25 August 2010, Pages 4526-4529
نویسندگان
Ashraf A. El-Shehawy, Nabiha I. Abdo, Ahmed A. El-Barbary, Jae-Suk Lee,