کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5269119 | 1385381 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spontaneous and diastereoselective aldol reactions of cyclic β-amino ketones in the presence of water
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Spontaneous and diastereoselective aldol reactions of cyclic β-amino ketones in the presence of water Spontaneous and diastereoselective aldol reactions of cyclic β-amino ketones in the presence of water](/preview/png/5269119.png)
چکیده انگلیسی
Direct aldol reactions of 4-methyl-1-piperidone, tropinone and granatanone (pseudopelletierine) take place spontaneously in the presence of water without any catalyst or additional reagents. The anti/syn-diastereoselectivity of the aqueous aldol reaction depends on the amount of water used. The syn-selectivity of the reaction is probably due to the thermodynamic control. Excellent atom economy and low E factors together with anti-selectivity as high as 98:2 for the tropinone aldol were obtained.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 43, 26 October 2011, Pages 5680-5683
Journal: Tetrahedron Letters - Volume 52, Issue 43, 26 October 2011, Pages 5680-5683
نویسندگان
Ryszard Lazny, Aneta Nodzewska, Iwona Tomczuk,