Enantioselective synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol: advanced intermediates of solandelactone A and B

An enantioselective synthesis of cyclopropyl δ-lactonealdehydes and dodecyl-5-ene-1-yne-3-ol is accomplished via organocatalytic and asymmetric transfer hydrogenation reactions as genesis of chirality. These precursors would envision culminating the synthesis of every representative member of the oxylipin class of natural products such as solandelactone A and B.