کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5269174 | 1385383 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of (Z)-fluoroallyl azides through aluminium-mediated defluorinative functionalization reactions
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of (Z)-fluoroallyl azides through aluminium-mediated defluorinative functionalization reactions Synthesis of (Z)-fluoroallyl azides through aluminium-mediated defluorinative functionalization reactions](/preview/png/5269174.png)
چکیده انگلیسی
The reaction of difluorohomoallyl alcohols with Me2AlCl in CH2Cl2 selectively gave (Z)-fluoroallyl chlorides via SN2â² type defluorinative chlorination. These chlorides were easily converted to the corresponding (Z)-fluoroallyl azides by the sequential nucleophilic azidation reaction using NaN3. Direct defluorinative azidation of the difluorohomoallyl alcohols was also achieved by treating with Me3SiN3 in the presence of Al(Oi-Pr)3. Fluoroallyl azides thus obtained successfully applied to the Huisgen 1,3-dipolar cycloaddition chemistry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 56, Issue 7, 11 February 2015, Pages 925-929
Journal: Tetrahedron Letters - Volume 56, Issue 7, 11 February 2015, Pages 925-929
نویسندگان
Azusa Sato, Hikaru Yanai, Daiki Suzuki, Midori Okada, Takeo Taguchi,