A general route to the synthesis of indoloazocines using allyl bromides prepared from Morita–Baylis–Hillman adducts

A general approach to the synthesis of (E)-5-(substituted) benzylidene-2,3,4,5-tetrahydro-1H-azocino[5,4-b]indol-6(7H)-ones via intramolecular Friedel Craft’s reaction of allylamines prepared from tryptamine and allyl bromides is reported.

Figure optionsDownload as PowerPoint slide