کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5269285 1385385 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective phosphorylation of diols with a Lewis acid catalyst
ترجمه فارسی عنوان
فسفوریلاسیون انتخابی دیول با کاتالیزور اسید لوئیس
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
We report a method for the Lewis acid catalyzed phosphorylation of diols with pyrophosphates. Titanium alkoxides were found to be effective catalysts in the selective mono-phosphorylation for a range of diols. Diols of varying chain lengths and substituents were screened, to study the factors that influence mono- versus di-phosphorylation. It was discovered that 2-alkyl-2-amino-1,3-propanediols can be selectively mono-phosphorylated in up to 97% isolated yield. This structural core is mono-phosphorylated in numerous immunomodulating compounds including the FDA-approved drug, FTY720.67
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 30, 23 July 2014, Pages 4203-4206
نویسندگان
, , , ,