کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5269453 1385389 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereoselective formal synthesis of aspergillide A
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Stereoselective formal synthesis of aspergillide A
چکیده انگلیسی
The stereoselective formal synthesis of aspergillide A (1), a cytotoxic 14-membered macrolide, is disclosed. The key intermediate, a trisubstituted tetrahydropyran core is prepared by SmI2-induced intramolecular reductive cyclization as well as by using sequential α-aminooxylation, Horner-Wadsworth-Emmons olefination, and followed by Oxa-Michael cyclization. Other notable transformations in the synthesis include the use of Jacobsen's hydrolytic kinetic resolution, esterification, ring-closing metathesis (RCM), and cross-metathesis (CM) reactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 51, Issue 32, 11 August 2010, Pages 4195-4198
نویسندگان
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