Site-selective Suzuki–Miyaura reactions of 2,3,5-tribromo-N-methylpyrrole

The first Suzuki–Miyaura reactions of 2,3,5-tribromo-N-methylpyrrole are reported. These reactions proceed with very good site-selectivity in favour of position 5 which is more reactive than position 2, due to steric reasons. The second attack occurs at position 2 which is more electron deficient than position 3.

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