Synthesis of 1,5-disubstituted tetrazoles via Suzuki-Miyaura cross-coupling of 5-chloro-1-phenyltetrazole

A catalyst and ligand screen for the Suzuki-Miyaura coupling of 1-phenyl-5-chlorotetrazole with a variety of aryl- and heteroaryl-boronic acids was conducted, which led to the identification of the optimal catalyst system for this transformation.