Efficient one-pot synthesis of functionalized piperidine scaffolds via ZrOCl2·8H2O catalyzed tandem reactions of aromatic aldehydes with amines and acetoacetic esters

A highly efficient diastereoselective one-pot synthesis of functionalized piperidines has been developed based on an aqua-compatible ZrOCl2·8H2O catalyst via tandem reactions of aromatic aldehydes, amines, and acetoacetic esters.

ZrOCl2·8H2O catalyzed highly diastereoselective efficient one-pot synthesis of functionalized piperidines from reactions of aromatic aldehydes, amines, and acetoacetic esters has been described.Figure optionsDownload as PowerPoint slide